ABSTRACT
Infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been growing swiftly worldwide. Patients with background chronic pulmonary inflammations such as asthma or chronic obstructive pulmonary diseases (COPD) are likely to be infected with this virus. Of note, there is an argument that COVID-19 can remain with serious complications like fibrosis or other pathological changes in the pulmonary tissue of patients with chronic diseases. Along with conventional medications, regenerative medicine, and cell-based therapy could be alternative approaches to compensate for organ loss or restore injured sites using different stem cell types. Owing to unique differentiation capacity and paracrine activity, these cells can accelerate the healing procedure. In this review article, we have tried to scrutinize different reports related to the harmful effects of SARS-CoV-2 on patients with asthma and COPD, as well as the possible therapeutic effects of stem cells in the alleviation of post-COVID-19 complications. Video abstract.
Subject(s)
Asthma , COVID-19 , Pulmonary Disease, Chronic Obstructive , Humans , SARS-CoV-2 , Pulmonary Disease, Chronic Obstructive/complications , Pulmonary Disease, Chronic Obstructive/drug therapy , Asthma/complications , Asthma/drug therapyABSTRACT
The severe acute respiratory syndrome coronavirus-2, a coronavirus, is known to cause acute respiratory distress syndrome and a range of non)respiratory effects, particularly in elderly male patients with underlying health conditions such overweight, diabetes, and hypertension. The coronavirus disease-2019 sequelae include multiple organ failure and neurological issues, and these prior health issues are linked to endothelial dysfunction. Although inhalation is the most frequent mode of infection, this virus has also been discovered in neurons, cerebrospinal fluid, the choroid plexus, and meningeal vasculature (English) [ FROM AUTHOR] Bir koronavirüs olan şiddetli akut solunum yolu sendromu koronavirüsü-2’nin, özellikle obezite, diyabet ve hipertansiyon gibi sağlık sorunları olan yaşlı erkek hastalarda akut solunum sıkıntısı sendromuna ve bir dizi solunum dışı sekellere neden olduğu bilinmektedir. Bu sağlık sorunları endotel disfonksiyonla bağlantılıdır ve koronavirüs hastalığı-2019 sekelleri, çoklu organ yetmezliği ve nörolojik sorunları içerir. Solunum birincil enfeksiyon modu olsa da, bu virüs koroid pleksus ve meningeal arterlerin yanı sıra nöronlar ve beyin omurilik sıvısı dahil olmak üzere çeşitli organlarda keşfedilmiştir (Turkish) [ FROM AUTHOR] Copyright of Turkish Journal of Immunology is the property of Galenos Yayinevi Tic. LTD. STI and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full . (Copyright applies to all s.)